How Global South Research Can Shape the Future of Comparative Physiology Comparative physiology, a discipline of physiology that exploits the understanding of how different animals function, provides the critical link to understand how organismal performance determines geographical distributions of animals. The many exquisite adaptations to extreme environments also provide valuable animal models to understand disease[…]

Single Cell View 3D Genome Architecture The 3-dimensional (3D) folding of the genome sequence inside the eukaryotic nucleus is tightly linked to cell function and identity. For that reason, deciphering the rules that govern 3D genome architecture is currently an important challenge facing biology. Determining genome architecture at the level of looping DNA-to-DNA interactions and/or[…]

Novel Technologies for Programming Human Cell Fate The reprogramming field has been firmly established, where we now have the capability of engineering a variety of cell identities. However, the protocols to generate target cell types are often inefficient and lack fidelity, with the engineered cells not fully recapitulating target identity. Previous studies aiming to assess[…]

Toxic Metabolites in the Biology of Ageing and Cancer Toxic metabolites in our metabolism, diet and in pollution have a major impact on human health. For example, alcohol and sugar toxic metabolites contribute to global mortality, ageing, diabetes, neurodegeneration and cancer. In the past decade, there has been a transformation in our understanding of how[…]

Developmental Metabolism and the Origins of Health and Disease Metabolism is central to the functions of all cells and its importance in the field of cancer has been clear for many years. Much more recently, developmental biologists have begun to appreciate how metabolism intersects with the processes of growth, patterning and differentiation. The developmental origins[…]