Genotype to Phenotype: Bridging Comparative Genomics and Cell Biology

Organisers: Gautam Dey and Eelco C. Tromer

Date: 13-16 November, 2022

Location: Buxted Park, East Sussex, UK

Enabled by the plummeting costs of sequencing and greatly improved analytical tools, today’s cell biologists have an unprecedented opportunity to place decades of model systems research within a comparative, evolutionary framework. However, we lack the ability to accurately map genotype to phenotype. Is it possible to accurately infer or predict cellular morphology, dynamics and function from genomic data? Moreover, once we understand a key regulator’s molecular function and cellular role in any given model, can we predict how its orthologs will behave in a novel or reconstructed genomic context and cellular milieu?

In this Workshop, we aim to bring together computational, cell, and evolutionary biologists to help address this major challenge of integrative cell biology. We strongly believe that actively seeking out collaboration across fields will be crucial to push cell biology beyond the boundaries of individual species into a truly comparative discipline anchored to predictive models. In turn, computational biologists will have an opportunity to guide and influence the next phase of big data generation in cell biology. Together, in deciphering the rules that underpin the relationship between the genome and the cell that encases it, we will better understand both evolution and cellular function.

About Buxted Park

The Workshop will be held at the beautiful Buxted Park in East Sussex which dates back to the 12th century. The current house was built in 1722 by Sir Thomas Medley and is an elegant Grade II Palladian mansion set in 312 acres of parkland. Over the years it has played host to a number of high profile visitors including William Wordsworth, Winston Churchill, and George V and Queen Mary. Whilst it was a health hydro in the 1960s Gregory Peck, Dudley Moore and Marlon Brando were regular visitors.

Buxted Park is less than 25 miles from Gatwick Airport and 60 miles from Heathrow Airport. There are direct trains taking 1 hour 10 minutes from London Bridge to the village of Buxted which is only a mile away from the hotel.

Buxted Park Hotel
Station Road
East Sussex
TN22 4AY
Tel: +44 (0) 1825 733333


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