Toxic Metabolites in the Biology of Ageing and Cancer

Organisers: KJ Patel and Liz Patton

Date: 4 - 7 December 2022

Location: Buxted Park, East Sussex, UK

Toxic metabolites in our metabolism, diet and in pollution have a major impact on human health. For example, alcohol and sugar toxic metabolites contribute to global mortality, ageing, diabetes, neurodegeneration and cancer. In the past decade, there has been a transformation in our understanding of how toxic metabolites contribute to ageing and disease – where they come from, how organisms protect themselves against them, and how their accumulation can damage certain stem cells.

This Workshop will focus on the biology of toxic metabolites in the ageing process, stem cells and cancer. Specific emphasis will be placed on how metabolites that carry carbonyls (such as aldehydes and ketones) damage stem and cancer cells. A particular area will focus on endogenous aldehydes (such as acteladehyde, formaldehyde and methyl-gyoxal), the enzymes that remove them [aldehyde dehydrogenases (Aldh) and functionally related glutathione-based enzymes such as Adh5 and Glo-1/2]. Further, we will consider how human genetic variation can contribute to metabolite sensitivity, and how mutations in cancer genomes in toxic metabolism pathways can be exploited for therapy.

This Workshop is a first-in-kind that will focus on these reactive carbonyls and their role in ageing and disease. We bring together young and established investigators from basic, clinical and industry science to explore new avenues of how toxic metabolites and associated metabolising enzymes function in disease for the long-term benefit of stem-cell and cancer therapies.

An important outcome of this Workshop is to foster new collaborations and to promote the exchange of ideas on the function of ALDH and related enzymes. The investigators presented here are from a range of disciplines (basic science, clinical and industry) with diverse specialities in genetics, genomics, metabolism, chemistry, biochemistry, structural biology, cancer biology, drug development and animal models.

About Buxted Park

The Workshop will be held at the beautiful Buxted Park in East Sussex which dates back to the 12th century. The current house was built in 1722 by Sir Thomas Medley and is an elegant Grade II Palladian mansion set in 312 acres of parkland. Over the years it has played host to a number of high profile visitors including William Wordsworth, Winston Churchill, and George V and Queen Mary. Whilst it was a health hydro in the 1960s Gregory Peck, Dudley Moore and Marlon Brando were regular visitors.

Buxted Park is less than 25 miles from Gatwick Airport and 60 miles from Heathrow Airport. There are direct trains taking 1 hour 10 minutes from London Bridge to the village of Buxted which is only a mile away from the hotel.

Buxted Park Hotel
Station Road
East Sussex
TN22 4AY
Tel: +44 (0) 1825 733333


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