The Cytoskeletal Road to Neuronal Function
Organisers: Andrew Carter, Carsten Janke and Oren Schuldiner
Date: 15 – 18 April 2024
Location: Buxted Park, East Sussex, UK
The cytoskeleton is a key structure of every living cell. In eukaryotes, microtubule and actin filaments are ubiquitous cytoskeletal elements which are adapted to perform a multitude of different functions. Neurons are particularly dependent on their cytoskeleton which plays key roles spanning from neuronal differentiation and migration, through axonal trafficking and synapse formation, to neurodegeneration and cell death.
In this Workshop we will bring together scientists from a wide spectrum of disciplines that would therefore not commonly have the chance to interact closely: neurobiologists with background in cellular, developmental and systems neurobiology, as well as structural biologists and biochemists from the cytoskeleton field. Our aim is to delineate how basic molecular and structural knowledge from the cytoskeleton field can help understanding neuronal processes that take place on a larger scale, such as neuronal development and connectivity, neuronal transmission, and also neurodegeneration. We will discuss among other questions: Why do mutations in cytoskeletal components result in specific subsets of neurons dying or failing to migrate properly? How is the cytoskeleton involved in memory generation, processing and storage?
Combining our increased understanding of structural and biochemical aspects of microtubules, actin filaments and motors, with refined tools to study neuronal functions in organisms makes this an especially exciting time to bring people together. Our goal is to discuss novel ideas and form new, fruitful collaborations in a small and focussed setting. We anticipate that our Workshop will catalyse a strong interdisciplinary approach to explaining some of the key molecular processes involved in the formation of a brain, its function and how it goes wrong in diseases from dementias to psychiatric disorders.
Organisers & speakers
Andrew Carter MRC Laboratory of Molecular Biology, UK
Carsten Janke Institut Curie, France
Oren Schuldiner Weizmann Institute of Science, Israel
Peter Bieling Max Planck Institute of Molecular Physiology, Germany
Frank Bradke DZNE, Germany
Valeria Cavalli Washington University in St. Louis, USA
Bianxiao Cui Stanford University, USA
Filippo Del Bene Institut de la Vision, France
Elizabeth Engle Harvard Medical School, USA
Aurnab Ghose Indian Institute of Science Education and Research Pune, India
Michel Goedert MRC Laboratory of Molecular Biology, UK
Christian Gonzalez Billault Universidad de Chile, Chile
Erika Holzbaur University of Pennsylvania, USA
Lukas Kapitein Utrecht University, The Netherlands
Thomas Misgeld Technical University of Munich, Germany
Naoko Mizuno National Heart, Lung, and Blood Institute, USA
Guangshuo Ou Tsinghua University, China
Ewa Paluch University of Cambridge, UK
Melissa Rolls Penn State, USA
Alison Twelvetrees University of Sheffield, UK
Shaul Yogev Yale University, USA
We offer up to 10 funded places for early-career researchers (PhD, postdocs and PIs in the first three years of their first appointment) to attend our Workshops along with the invited speakers. We just ask that you pay for your own travel costs. If you would like to attend please complete the online application form and include a one page CV and a letter of support from your supervisor. If your supervisor would prefer to send the letter directly to us please ask them to email it to firstname.lastname@example.org
All attendees are expected to actively contribute to the Workshops by asking questions at presentation sessions and taking part in discussions, as well as giving a short talk on their research.
At some Workshops, early-career researchers are given additional responsibilities to promote their involvement, such as:
- Write a daily blog for the Node
- Summarise the previous day’s themes to set the scene for the next day’s sessions
- Propose future directions and collaborations
- Make a short two minute video on their experience at the Workshop
Most of these activities would be carried out in pairs or small groups and often with the support of more senior scientists present.
About Buxted Park
The Workshop will be held at the beautiful Buxted Park in East Sussex which dates back to the 12th century. The current house was built in 1722 by Sir Thomas Medley and is an elegant Grade II Palladian mansion set in 312 acres of parkland. Over the years it has played host to a number of high profile visitors including William Wordsworth, Winston Churchill, and George V and Queen Mary. Whilst it was a health hydro in the 1960s Gregory Peck, Dudley Moore and Marlon Brando were regular visitors.
Buxted Park is less than 25 miles from Gatwick Airport and 60 miles from Heathrow Airport. There are direct trains taking 1 hour 10 minutes from London Bridge to the village of Buxted which is only a mile away from the hotel.
Buxted Park Hotel
Tel: +44 (0) 1825 733333
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