...

Anti-ageing in the Greenland Shark

The Greenland Shark, Somniosus microcephalus, has remarkable longevity and is the longest-living vertebrate known to science. The decline of shorter-lived species involves the loss of DNA integrity via the loss of DNA repair mechanisms. The longevity of the Greenland Shark suggests resilience to this age-related functional decline.

To test the hypothesis that Greenland Shark DNA is unique in this respect, Pierre Delaroche travelled from Dr Holly Shiels’ lab at the University of Manchester to the University of Copenhagen’s Arctic Station on Disko Island in Greenland with Professor John Fleng Steffensen. 

Putting forces under the microscope with a Travelling Fellowship

The three-dimensional mechanical forces generated during the activation of T lymphocytes have been quantified at unprecedented spatiotemporal resolution. To do so, Postdoctoral Researcher Huw Colin-York from the Fritzsche Group, which studies Biophysical Immunology at the University of Oxford, travelled to the laboratory of Prof Dong Li at the Chinese Academy of Sciences, Institute of Biophysics, Beijing, courtesy of a Travelling Fellowship from the Journal of Cell Science.

Expanded understanding of leukaemia treatment

Transplantation of hematopoietic stem cells (HSC – stem cells that produce new blood cells) is a common treatment for several leukaemias. Following transfusion, HSCs migrate from the circulatory system into bone marrow niches, where they begin a process of self-renewal and proliferation that supports lifelong normal blood cell production.

Transfer of experience

Intranasal insulin has been shown to improve memory in both humans and mice. However, in most cases less than 0.05% of insulin delivered via the intranasal route actually reaches the brain. Buccal epithelium is routinely used as an in vitro model for investigating peptide uptake, but Elizabeth Rhea, a postdoctoral fellow in the Department of Medicine at the University of Washington, USA, wished to investigate its potential as a model for screening enhancers of intranasal insulin delivery.

Developing a framework of support

One of the research areas of the Martinez-Arias lab in the Department of Genetics at the University of Cambridge, UK, is the development of gastruloids – small, self-organising aggregates of mouse embryonic stem cells. PhD student Peter Baillie-Johnson was working on the generation of elongating gastruloids to mimic the first stages of axial elongation in the mouse embryo, but was limited by aggregates adhering to the surface of culture plates.

New imaging approach unveils a bigger picture

As intelligent problem-solvers and devious escape artists with the ability to change colour, skin texture and shape, octopuses have captured the minds of researchers for good reason. Hydrostats make up the octopus’ most well-known feature, its eight arms. These muscular structures lack skeletal support, which provides octopuses with a high degree of flexibility that is visible in their ability to explore and manipulate small objects. 

Photoimmunotherapy – shedding a new light on glioblastoma treatment

Dr. Malgorzata Kucinska in the lab

Glioblastoma multiforme (GBM), a grade IV brain tumor, is the most common malignant primary brain cancer in adults. Patients with GBM have a poor prognosis following standard therapy, with a 5-year survival rate of only 3-5%. Although novel therapies against GBM have been tested, the standard care has remained unaltered for over 15 years.

Collaboration spawns new findings

The research project of PhD student Filomena Caccavale at the Stazione Zoologica Anton Dohrn in Naples, Italy, has focussed on the role of nitric oxide (NO) during embryonic and larval development of the cephalochordate Branchiostoma lanceolatum (amphioxus).

Paying it forward

As a new assistant professor at James Cook University (JCU), marine conservation physiologist Jodie Rummer applied to the Journal of Experimental Biology for a Travelling Fellowship to perform fieldwork at Lizard Island Research Station in the Northern Great Barrier Reef of Australia.

Visualising the bacterial cytoskeleton

The bacterial cytoskeleton controls many important cellular processes including bacterial cell morphogenesis, division and motility. Elements of the bacterial cytoskeleton mirror the major components of the cytoskeleton in eukaryotic cells; for example, the actin homologue MreB, the tubulin homologue FtsZ and the intermediate filament homologue CreS.

Latest Company News


Visit our journal websites

Development Journal of Cell Science The Journal of Experimental Biology Disease Models & Mechanisms Biology Open

© 2019 The Company of Biologists Ltd | Registered Charity 277992
Registered in England and Wales | Company Limited by Guarantee No 514735
Registered office: Bidder Building, Station Road, Histon, Cambridge CB24 9LF, UK