Chromatin-Based Regulation of Development

Organisers: Benoit Bruneau and Joanna Wysocka

Date: 14 - 17 April 2019

Location: Wiston House, UK

The field of developmental biology has often intersected with the exploration of gene regulatory mechanisms. Indeed, much of our knowledge of the mechanisms of embryonic development stems from the analysis of the function of transcriptional regulators, including modulators of chromatin. Conversely, classic discoveries in chromatin-level regulation of gene expression have arisen from developmental models. This workshop takes advantage of the pace of innovation and discovery in the field of chromatin biology, and its potential for revealing exciting new insights into developmental processes. From genome-scale regulation of histones to three-dimensional folding of chromatin, recent years have seen an explosion of discovery, some of which has been in a developmental setting. Furthermore, progress in quantitative imaging and single-cell genomic approaches provided first glimpses into kinetics and heterogeneity underlying developmental gene regulation. This workshop brings together scientists who can or would like to bridge chromatin-level gene regulation, quantitative approaches and developmental biology.

The workshop will foster an open discussion of what mechanisms related to chromatin biology are informing developmental processes, and will explore what concrete plans could be developed to integrate unsolved developmental questions with exciting new avenues in chromatin biology. In turn, we will discuss which outstanding questions in gene regulation might be best revealed in the context of dynamic cell fate transitions. Ultimately, we hope to promote scientific interactions that will open up new approaches to both fields, via collaborations or cross-pollination of techniques, knowledge, and data types.


About Wiston House

Wiston House

The Workshops will be held at the beautiful Wiston House, which is a 16th century Grade I listed building located at the foot of the South Downs in West Sussex. The house is surrounded by over 6,000 acres of parkland with magnificent views from the mile-long drive.

Wiston House is the home of Wilton Park, one of the world’s leading centres for the discussion of key international policy issues. Wilton Park was created in 1946 to help re-establish peace and democracy in Europe as part of an initiative inspired by Winston Churchill. Wiston House has an amazing history and appears in the Domesday Book, the register of English possessions made by William the Conqueror in 1086, 20 years after he won the Battle of Hastings.

Wiston House is 32 miles from Gatwick Airport and 60 miles from Heathrow Airport. The nearest train station is Shoreham-by-Sea, which is a 20 minute taxi ride from Wiston House and takes 1 hour 10 minutes from London Victoria.

Wiston House
Steyning Road
West Sussex
BN44 3DZ
Tel: +44 (0) 1903 815020

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