Pre-clinical Modelling of Human Genetic Disease and Therapy
Organisers: Wendy Bickmore, Luke Boulter, Sara Brown, Pleasantine Mill, Liz Patton and Owen Sansom
Date: 8 – 10 May 2024
Location: Institute of Genetics and Cancer, University of Edinburgh, UK
Rapid advances in gene editing and genetic technologies have revolutionised our ability to model human genetic disease and provided new hope for gene therapies. At this meeting, we will present the very latest advances in modelling human genetic disease, from rare disease, cancer and immune disorders through to genetic modifiers. We will also discuss the latest technologies and the challenges associated with generating relevant human genetic mutations in multi-modal systems, including advanced complex cellular models, model organisms and large animal models, and how genetic technologies can be applied to genome-wide screens and therapy. In addition, speakers will outline the latest strategies to model genetic mutations in cell type and tissue-specific mechanisms, in a developmental and time-dependent fashion, and in the coding and non-coding genome. Importantly, we will also discuss the latest approaches to the phenotyping of models and how to computationally align models with human disease to guide therapeutic intervention and, ultimately, translation.
Organisers
Luke Boulter University of Edinburgh, UK
Sara Brown University of Edinburgh, UK
Pleasantine Mill University of Edinburgh, UK
Liz Patton University of Edinburgh, UK
Owen Sansom Beatson Institute of Cancer Research, Glasgow, UK
Speakers
James Amatruda Children’s Hospital Los Angeles, USA
Adrian Bird University of Edinburgh, UK
Karen Blyth Beatson Institute for Cancer Research, UK
Ross Cagan University of Glasgow, UK
Ramanuj DasGupta A*STAR Genome Institute of Singapore, Singapore
James Dowling University of Toronto, Canada
Cathy Fernandes King’s College London, UK
Laura Greaves Newcastle University, UK
Alberto Kornblihtt University of Buenos Aires, Argentina
Karen Liu King’s College London, UK
Cecilia Lo University of Pittsburgh, USA
Cristina Lo Celso Imperial College London, UK
Daniel Peeper The Netherlands Cancer Institute, The Netherlands
Steven Pollard University of Edinburgh, UK
Fiona Powrie University of Oxford, UK
Jason Rihel University College London, UK
John Sayer Newcastle University, UK
Angelika Schnieke TUM School of Life Sciences, Technical University of Munich, Germany
Stefan Somlo Yale School of Medicine, USA
Ellen van den Bogaard Radboud University Medical Center, The Netherlands
Eckhard Wolf University of Munich, Germany
Andrew Wood University of Edinburgh, UK
Hao Zhu University of Texas, Southwestern Medical School, USA
Registration packages
The meeting will open to applications in Autumn 2023. Please register your interest in the meeting to receive updates on speakers and key dates.
The meeting will start with registration at midday on Wednesday 8 May 2024, and will run through to the end of the day on Friday 10 May 2024.
The fees include:
- Registration and meeting costs
- Day 1: Coffee break and reception drinks
- Day 2: Two coffee breaks, lunch and reception drinks
- Day 3: Two coffee breaks and lunch
N.B. Evening meals are not included, with the exception of Thursday 9 May, which can be added as an option at registration.
It is expected that all attendees will stay for the duration of the meeting.
| Prices (including dinner) | PhD students /postdocs | Academia | Industry |
| Until 8 December 2023 | £110 | £185 | £335 |
| 9 December 2023 – 8 March 2024 |
£135 | £235 | £385 |
| Prices (not including dinner) | PhD students /postdocs | Academia | Industry |
| Until 8 December 2023 | £75 | £150 | £300 |
| 9 December 2023 – 8 March 2024 |
£100 | £200 | £350 |
Meeting dinner
The meeting dinner will take place on Thursday 9 May, at the Royal College of Physicians on Queen Street, Edinburgh.
Set in the heart of Edinburgh’s city centre, the college is historic and elegant, with stunning architecture and medical symbolism weaved throughout.
Drinks will be served in the New Library, followed by a seated meal in the magnificent Victorian Grand Hall.
A shuttle bus service will be provided to take attendees to dinner from the conference venue, and will drop off attendees at the designated drop-off points at the end of the evening.
Key dates
Registration opens: 23 September 2023
Early-bird deadline: 8 December 2023
Abstract submission deadline: 9 February 2024
Final registration and payment deadline: 8 March 2024
Image courtesy of Vito Antonio Baldassarro and Laura Calzà (University of Bologna, Italy)
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