Cell Size and Growth, from Single Cells to the Tree of Life

Organisers: Clotilde Cadart and Matthew Swaffer

Date: 3 - 6 April 2022

Location: Buxted Park, East Sussex, UK

Cell size is tightly linked to cellular physiology – it sets the scale of subcellular compartments, cellular biosynthetic capacity, metabolism, mechanical properties, surface-to-volume ratios, and molecular transport. Changes in cell size are also associated with many disease states such as cancer and ageing.

How cell size impacts these different cellular processes and how cells control their size are long-standing but unresolved questions in cell biology. Recent developments have brought important insights but have also emphasised the breadth of remaining unanswered questions. For example, the molecular mechanisms that couple cellular biosynthesis or organelle scaling with cell volume are still largely mysterious. Even less is known about cell size regulation within complex environments such as plant or animal tissues, or how changes in cell size may impact biological function at the cellular or tissue level.

The primary aim of this workshop is to bring together world-leading researchers working on a diversity of questions related to cell size across a range of model systems.

It is also well established that such scaling relationships exist across species. For example, cell size, nuclear size, genome size and developmental rate show pronounced scaling relationships with one another across the tree of life. These observations suggest the existence of some fundamental principles that link genome size, cell size and whole-organism physiology across species. However, at present there is a disconnect between the cell size field and research focused on scaling relationships between species across evolutionary time-scales. To bridge the gap between these two lines of research, this workshop also aims to connect cell biologists with scientists from ecology and evolutionary biology.

The workshop will offer a highly interactive and discursive environment, where researchers are invited to present their most recent unpublished work.

About Buxted Park

The Workshop will be held at the beautiful Buxted Park in East Sussex which dates back to the 12th century. The current house was built in 1722 by Sir Thomas Medley and is an elegant Grade II Palladian mansion set in 312 acres of parkland. Over the years it has played host to a number of high profile visitors including William Wordsworth, Winston Churchill, and George V and Queen Mary. Whilst it was a health hydro in the 1960s Gregory Peck, Dudley Moore and Marlon Brando were regular visitors.

Buxted Park is less than 25 miles from Gatwick Airport and 60 miles from Heathrow Airport. There are direct trains taking 1 hour 10 minutes from London Bridge to the village of Buxted which is only a mile away from the hotel.

Buxted Park Hotel
Station Road
East Sussex
TN22 4AY
Tel: +44 (0) 1825 733333


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