A small selection of Open Access articles on metabolism from The Company of Biologists’ journals
METHODS & TECHNIQUES
Development of a diet-induced murine model of diabetes featuring cardinal metabolic and pathophysiological abnormalities of type 2 diabetes
Jodie L. Morris, Tahnee L. Bridson, Md Abdul Alim, Catherine M. Rush, Donna M. Rudd, Brenda L. Govan, Natkunam Ketheesan
Summary: We describe a murine model of type 2 diabetes based on chronic consumption of an energy-dense diet. Longitudinal sampling demonstrates metabolic and pathological changes closely simulating progression to overt diabetes.
Metabolite profile of a mouse model of Charcot–Marie–Tooth type 2D neuropathy: implications for disease mechanisms and interventions
Preeti Bais, Kirk Beebe, Kathryn H. Morelli, Meagan E. Currie, Sara N. Norberg, Alexei V. Evsikov, Kathy E. Miers, Kevin L. Seburn, Velina Guergueltcheva, Ivo Kremensky, Albena Jordanova, Carol J. Bult, Robert W. Burgess
Biology Open 2016 5: 908-920; doi: 10.1242/bio.019273
Summary: A metabolomics analysis of a mouse model of Charcot–Marie–Tooth type 2D neuropathy revealed a clear distinction between mutant and control samples, and the therapeutic potential of a subset of these changes was explored.
The effects of laboratory housing and spatial enrichment on brain size and metabolic rate in the eastern mosquitofish, Gambusia holbrooki
Mischa P. Turschwell, Craig R. White
Summary: The discovery of a difference in brain size between adult mosquitofish living in the wild, in spatially enriched tanks and in bare tanks has implications for the effect of environmental enrichment on transferability of data from laboratory animals to their wild counterparts.
To boldly gulp: standard metabolic rate and boldness have context-dependent influences on risk-taking to breathe air in a catfish
David J. McKenzie, Thiago C. Belão, Shaun S. Killen, F. Tadeu Rantin
Journal of Experimental Biology 2015 218: 3762-3770; doi: 10.1242/jeb.122903Highlighted Article: Air is much richer in oxygen than water, but surfacing to gulp air can require boldness in the air-breathing catfish.
The Menkes and Wilson disease genes counteract in copper toxicosis in Labrador retrievers: a new canine model for copper-metabolism disorders
Hille Fieten, Yadvinder Gill, Alan J. Martin, Mafalda Concilli, Karen Dirksen, Frank G. van Steenbeek, Bart Spee, Ted S. G. A. M. van den Ingh, Ellen C. C. P. Martens, Paola Festa, Giancarlo Chesi, Bart van de Sluis, Roderick H. J. H. Houwen, Adrian L. Watson, Yurii S. Aulchenko, Victoria L. Hodgkinson, Sha Zhu, Michael J. Petris, Roman S. Polishchuk, Peter A. J. Leegwater, Jan Rothuizen
Lauren E. Nadler, Shaun S. Killen, Eva C. McClure, Philip L. Munday, Mark I. McCormick
Journal of Experimental Biology 2016 219: 2802-2805; doi: 10.1242/jeb.139493Highlighted Article: Group living reduces metabolic rate in a shoaling damselfish species, while isolation reduces body condition. Social isolation due to environmental disturbance may therefore have physiological consequences for gregarious species.
Thi Loan Anh Nguyen, Sara Vieira-Silva, Adrian Liston, Jeroen Raes