Metabolism in Development and Disease

Organisers: Suzanne Eaton, Wilhelm Palm and Craig Thompson

Date: 15th - 18th May 2016

Location: Wiston House, Steyning, West Sussex, UK

In 1925, Otto Warburg noted that many types of cancer cells derive energy from glycolysis rather than oxidative phosphorylation even in the presence of oxygen. Over the last decade, this observation has received renewed attention from cancer biologists, and it has emerged that specialized metabolic wiring (including “Warbug” metabolism) is key to supporting the production of biomass necessary for growth. How metabolic adaptations might regulate growth during development and regeneration has been less well explored, but these ideas are beginning to interest developmental and stem cell biologists. Genetic model organisms will provide powerful systems with which to understand how metabolism is regulated in development and how it changes as cells differentiate and tissues approach their final size and stop growing. Understanding how growth-promoting metabolism is normally coordinated with development will be critical to deciphering how these mechanisms are deregulated in cancer.

To achieve this synthesis, the workshop will bring together researchers interested in cancer metabolism with developmental biologists interested in growth regulation. Cross-fertilization of ideas across these disciplines will inspire new research directions and collaborations. To this end, sufficient time for discussions and non-formal interactions will be provided.

Workshop sessions will be focused on:
1) cell metabolism and growth
2) metabolic cooperation and competition between cells
3) metabolic sensing
4) cell metabolism in normal development

The Company of Biologists’ Workshops only take place three times per year, on topics that are driving forward the progress of life sciences and biomedical research. The meetings are small and intensive, taking place over 3 days with 20 invited participants, all of whom we ask to make a presentation, and a further 10 chosen from submitted applications (students and postdocs as well as junior PIs). A condition of attendance is that you are present for the full meeting, from Sunday lunchtime through to Wednesday lunchtime.

ATP FRET signals at different times after blocking oxidative phosphorylation in a growing wing disc of Drosophila. ATP FRET signals at different times after blocking oxidative phosphorylation in a growing wing disc of Dropsophila.










ATP FRET signals at different times after blocking oxidative phosphorylation in a growing wing disc of Dropsophila. Image courtesy of Venkatesan Iyer.


About Wiston House

Wiston House

The Workshops will be held at the beautiful Wiston House, which is a 16th Century Grade I listed building located at the foot of the South Downs in West Sussex. The House is surrounded by over 6,000 acres of parkland with magnificent views from the mile-long drive.

Wiston House is one of the world’s leading centres for the discussion of key international policy issues. It was created in 1946 to help re-establish peace and democracy in Europe as part of an initiative inspired by Winston Churchill. Wiston House has an amazing history and appears in the Domesday Book, the register of English possessions made by William the Conqueror in 1086, 20 years after he won the Battle of Hastings.

Wiston House is 32 miles from Gatwick Airport and 60 miles from Heathrow Airport. The nearest train station is Shoreham-by-Sea, which is a 20 minute taxi ride from Wiston House and takes 1 hour 10 minutes from London Victoria.

Wiston House
Steyning Road
West Sussex
BN44 3DZ
Tel: +44 (0) 1903 815020

About our Workshops

The Company of Biologists is widely known for its excellence in scientific publishing and it now runs a successful high level series of Workshops. The Workshops provide leading experts and early career scientists from a diverse range of scientific backgrounds with a stimulating environment for the cross fertilization of interdisciplinary ideas. The programmes are carefully developed and are intended to champion the novel techniques and innovations that will underpin important scientific advances.

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The teams behind our journals bring you the most relevant and challenging topics for discussion through a series of international meetings.

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Each meeting is individually crafted to suit the topic and audience, ranging from small intimate meetings with a focus on intense and detailed discussion to larger meetings with a focus on networking and opportunities for attendees to more widely share their latest research.

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