The Biology and Physics of Left-Right Patterning

Organisers: Gonca Erdemci-Tandogan and Daniel Grimes

Date: 5 - 8 June 2022

Location: Buxted Park, East Sussex, UK

Left-right asymmetry is a common feature of animal bodies. For instance, the internal organs of vertebrates are highly asymmetric, something which is essential for their functions. Multiple developmental processes –  from initial breaking of embryonic symmetry and asymmetric patterning of the embryo, through to asymmetric morphogenesis of the organs – contribute to generating a functional left-right asymmetric animal.

This Workshop aims to bring together scientists from diverse backgrounds, including genetics, developmental biology, physics and computational biology, to understand how left-right asymmetries are generated in animals. Topics include imaging and modelling of the cilia-driven fluid flows involved in breaking embryonic symmetry in some organisms; flow sensation mechanisms; gene regulatory networks that pattern the embryo asymmetrically; and cell biology and mechanics of asymmetric organogenesis. Discussions will also include how defects in left-right asymmetry result in diseases and how mechanisms that generate asymmetries have changed (or stayed the same) through evolution.

1) Diverse mechanisms of symmetry-breaking
2) Cilia and fluid flow in left-right asymmetry
3) Left-right asymmetric patterning of the embryo
4) Left-right asymmetric organ morphogenesis
5) Diseases associated with defective left-right patterning
6) Left-right patterning mechanisms through evolution

Our goal is to provide an opportunity for a diverse group of scientists to foster interdisciplinary collaborations and create an environment that encourages us all to tackle the long-standing questions in left-right asymmetry, as well as to frame the next questions.

About Buxted Park

The Workshop will be held at the beautiful Buxted Park in East Sussex which dates back to the 12th century. The current house was built in 1722 by Sir Thomas Medley and is an elegant Grade II Palladian mansion set in 312 acres of parkland. Over the years it has played host to a number of high profile visitors including William Wordsworth, Winston Churchill, and George V and Queen Mary. Whilst it was a health hydro in the 1960s Gregory Peck, Dudley Moore and Marlon Brando were regular visitors.

Buxted Park is less than 25 miles from Gatwick Airport and 60 miles from Heathrow Airport. There are direct trains taking 1 hour 10 minutes from London Bridge to the village of Buxted which is only a mile away from the hotel.

Buxted Park Hotel
Station Road
East Sussex
TN22 4AY
Tel: +44 (0) 1825 733333


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