Virtual Workshop: Inflammaging and Regeneration: Pain or Partnership?

Organisers: Helen Blau and Nadia Rosenthal

Date: 2 - 4 August 2021

Location: Online

The immune system relies on acute inflammation to mitigate infections, clear damaged cells and initiate tissue healing. A transient painful inflammatory response is tightly linked to regeneration, and an appreciation of the significance of this interplay in translational research is rapidly increasing. Moreover, many of the mechanisms that link inflammation to regeneration are rendered dysfunctional by the aging process. The progressive accumulation of senescent cells over time fosters a chronic milieu of inflammation termed “inflammaging”, leading to poor tissue repair and degenerative disease.

Age-related changes in immunity are characterized by a combination of adaptive immunity impairment and a persistent inflammatory response, which contribute to the progression of age-associated diseases that drives the aging process. Moreover, acute inflammatory responses to pathogens may be weakened in aging, leading to increased susceptibility to infection. We have an incomplete picture of the hierarchies in immune determinants that orchestrate effective tissue regeneration, and the divergent immune phenotypes that derail these processes.

This Workshop will bring together experts in two communities –immunology and regeneration — to explore the mechanisms underlying immune-mediated tissue turnover, adaptation and repair, and the complex remodeling of the immune system associated with aging. We will focus on the paradoxical need for transient inflammation in the regenerative process and co-existence of chronic inflammation and immunodeficiency that accompanies tissue senescence; the cellular and molecular cascades that allow responding cells to proliferate and either induce healthy healing or cause scarring; the age-related changes in macrophage polarization dynamics and adaptive immune responses that drive immune and stromal cells to both initiate and terminate healing responses; and the potential to target the regenerative functions that go awry with immunomodulators and senolytics. Designing interventions for therapeutic purposes is particularly challenging in the setting of aging, where homeostatic replacement of healthy tissue has been distorted, requiring a synergy of immunology and regenerative biology disciplines and approaches.


Published Information from the Workshop
  • A Meeting report was written by Ludovic Gaut, Laura Muraine and was published on the Node in August 2021.


About our Workshops

The Company of Biologists is widely known for its excellence in scientific publishing and it now runs a successful high level series of Workshops. The Workshops provide leading experts and early career scientists from a diverse range of scientific backgrounds with a stimulating environment for the cross fertilisation of interdisciplinary ideas. The programmes are carefully developed and are intended to champion the novel techniques and innovations that will underpin important scientific advances.


About our Journal Meetings

The teams behind our journals bring you the most relevant and challenging topics for discussion through a series of international meetings.

Important meetings serving the communities around our journals.

Each meeting is individually crafted to suit the topic and audience, ranging from small intimate meetings with a focus on intense and detailed discussion to larger meetings with a focus on networking and opportunities for attendees to more widely share their latest research.

Themes explored in the Journal Meetings go on to be discussed in the Company’s journals, helping to shape the field and even the journals themselves.

Propose a new Workshop

If you have a vision for such a meeting but don’t have the time to arrange the logistics or raise the funding, then please contact us. We are seeking proposals for future Workshops and provide all necessary support.

Visit our journal websites

Development Journal of Cell Science The Journal of Experimental Biology Disease Models & Mechanisms Biology Open

© 2024 The Company of Biologists Ltd | Registered Charity 277992
Registered in England and Wales | Company Limited by Guarantee No 514735
Registered office: Bidder Building, Station Road, Histon, Cambridge CB24 9LF, UK