Blood Disorders: Models, Mechanisms and Therapies

Organisers: Monica Justice, Nancy Speck, Paresh Vyas and Leonard Zon

Date: 29 September - 1 October 2019

Location: Joseph B. Martin Conference Center, Boston, USA

Advancing basic research findings to the clinic remains a daunting task. Researchers in the field of hematopoiesis have made significant progress in this regard by taking discoveries from model organisms to the clinic. Such advances, including bone marrow transfers, stem cell replacements and immunotherapies, have also had a large impact on the treatment of non-blood disorders.

This meeting on blood disorders and their treatment, organised by the journal Disease Models & Mechanisms, was curated by Editor-in-Chief Monica Justice, Nancy Speck, Paresh Vyas and Leonard Zon. The meeting brought together diverse front-line researchers, stimulated discussions across basic research and clinical disciplines, and fostered collaborative links among researchers.

Talks featured basic research advances acquired across multiple model organisms, as they are applied to human blood disorders. A primary aim was to promote knowledge of therapies or drug discovery that has been developed pre-clinically to move to a clinical trial.


  • Blood development: mechanisms and pathology
  • Epigenetic regulation of blood development
  • Erythropoiesis and red cell disorders
  • Targeting blood cancers
  • Clonal hematopoiesis
  • Manipulating the stem cell niche

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Blood Disorders: Models, Mechanisms and Therapies
29 September – 1 October 2019
Joseph B. Martin Conference Center, Boston, USA

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