A small selection of Open Access articles on neurobiology from The Company of Biologists’ journals
Is this a brain which I see before me? Modeling human neural development with pluripotent stem cells
Ikuo K. Suzuki, Pierre Vanderhaeghen
Summary: This Review examines stem cell-based approaches to analysing human brain development, from specification of particular cell types to building neuronal networks.
Yang-In Yim, Bum-Chan Park, Rajgopal Yadavalli, Xiaohong Zhao, Evan Eisenberg, Lois E. Greene
Plamena R. Angelova, Marthe H. R. Ludtmann, Mathew H. Horrocks, Alexander Negoda, Nunilo Cremades, David Klenerman, Christopher M. Dobson, Nicholas W. Wood, Evgeny V. Pavlov, Sonia Gandhi, Andrey Y. Abramov
Summary: Monomeric and oligomeric α-synuclein induce Ca2+ signal in neurons and astrocytes by incorporating into the membrane.
Identifying the primary site of pathogenesis in amyotrophic lateral sclerosis – vulnerability of lower motor neurons to proximal excitotoxicity
Catherine A. Blizzard, Katherine A. Southam, Edgar Dawkins, Katherine E. Lewis, Anna E. King, Jayden A. Clark, Tracey C. Dickson
Small heat shock proteins mediate cell-autonomous and -nonautonomous protection in a Drosophila model for environmental-stress-induced degeneration
Fumiko Kawasaki, Noelle L. Koonce, Linda Guo, Shahroz Fatima, Catherine Qiu, Mackenzie T. Moon, Yunzhen Zheng, Richard W. Ordway
Summary: A Drosophila model for environmental-stress-induced degeneration exhibits key features for genetic analysis of degenerative disease mechanisms and reveals new forms of protection mediated by small heat shock proteins.
Michael H. Hayes, Daniel L. Weeks
Summary: Non-membrane-bound nuclear particles in Xenopus oocytes responsible for RNA transcription, modification and processing contain proteins assembled into amyloids as part of normal development.
Engrailed 1 shapes the dopaminergic and serotonergic landscape through proper isthmic organizer maintenance and function
Willemieke M. Kouwenhoven, Jesse V. Veenvliet, Johannes A. van Hooft, L. P. van der Heide, Marten P. Smidt
Summary: Local molecular coding under the influence of En1 is essential for proper spatiotemporal expression of key factors involved in the maintenance and function of the isthmic organizer.
STEM CELLS AND REGENERATION
Spinal motor neurons are regenerated after mechanical lesion and genetic ablation in larval zebrafish
Jochen Ohnmacht, Yujie Yang (杨宇婕), Gianna W. Maurer, Antón Barreiro-Iglesias, Themistoklis M. Tsarouchas, Daniel Wehner, Dirk Sieger, Catherina G. Becker, Thomas Becker
Summary: Regeneration of spinal motor neurons following mechanical lesion or genetic ablation occurs at the expense of oligodendrogenesis and is promoted by the innate immune system.