A small selection of Open Access articles on muscle from The Company of Biologists’ journals
Nicolas A. Dumont, Yu Xin Wang, Michael A. Rudnicki
Summary: This Review discusses how satellite stem cell behaviour is regulated during regeneration and degeneration by a complex balance between extrinsic cues and intrinsic regulatory mechanisms.
Fabio Demontis, Rosanna Piccirillo, Alfred L. Goldberg, Norbert Perrimon
Joe W. McGreevy, Chady H. Hakim, Mark A. McIntosh, Dongsheng Duan
Philippe Daubas, Nathalie Duval, Lola Bajard, Francina Langa Vives, Benoît Robert, Baljinder S. Mankoo, Margaret Buckingham
Summary: Homeodomain factors Msx1 and Meox2, acting in addition to Pax3 and Six1/4, fine-tune the entry of progenitor cells into myogenesis at early stages of forelimb development via modulation of limb enhancer gene Myf5.
HSPB7 interacts with dimerized FLNC and its absence results in progressive myopathy in skeletal muscles
Liang-Yi Juo, Wern-Chir Liao, Yen-Ling Shih, Bih-Ying Yang, An-Bang Liu, Yu-Ting Yan
Highlighted Article: HSPB7 plays a crucial role in the maintenance of the muscle integrity, possibly through stabilizing the function of FLNC.
Maximilian Michael Saller, Rosa-Eva Huettl, Philipp Hanuschick, Anna-Lena Amend, Paolo Alberton, Attila Aszodi, Andrea B. Huber
Highlighted Article: Sema3A–Npn-1 signaling cell autonomously influences phrenic nerve branching in the diaphragm and induces ectopic muscle formation through secondary mechanisms, possibly by Slit–Robo signaling.
Graded effects of unregulated smooth muscle myosin on intestinal architecture, intestinal motility and vascular function in zebrafish
Joshua Abrams, Zev Einhorn, Christoph Seiler, Alan B. Zong, H. Lee Sweeney, Michael Pack
Editors’ choice: Two newly identified Myh11 gene missense mutations discovered in a zebrafish enhancer-suppressor mutagenesis screen are reported. The mutations disrupt myosin regulation and ATPase activity in a graded fashion, and this correlated with their effects on intestinal and vascular physiology.
Elly Ordan, Talila Volk
Summary: The Drosophila homolog of pheromone convertase 2 (PC2), amontillado (Amon), is shown to contribute to Slit processing and further cleavage into an N-Slit, essential for Slit activity in directing muscle patterning.
Children and adults minimise activated muscle volume by selecting gait parameters that balance gross mechanical power and work demands
Tatjana Y. Hubel, James R. Usherwood
Journal of Experimental Biology 2015 218: 2830-2839; doi: 10.1242/jeb.122135Highlighted Article: The gross mechanics of walking and running children and adults support a new model for the costs dominating level terrestrial locomotion – muscle activation for mechanical work or power.
G. P. Sutton, M. Doroshenko, D. A. Cullen, M. Burrows
Journal of Experimental Biology 2016 219: 2127-2136; doi: 10.1242/jeb.133728Summary: Praying mantises, which use direct muscle contractions to generate jumps, have take-off velocities limited by the amount of power (energy/time) the muscles can produce.
TECHNIQUES AND RESOURCES
Valérie Vilmont, Bruno Cadot, Gilles Ouanounou, Edgar R. Gomes
Summary: Co-culture of rodent spinal cord explants and primary myoblasts provides an in vitro system to study fundamental aspects of neuromuscular junction formation, maintenance and dysfunction.