Aging

A small selection of  Open Access articles on aging from The Company of Biologists’ journals

REVIEW

Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells

Dido Carrero, Clara Soria-Valles, Carlos López-Otín

Disease Models & Mechanisms 2016 9: 719-735; doi: 10.1242/dmm.024711

Summary: This Review defines the molecular and cellular hallmarks of progeroid syndromes according to the main cellular and animal models, and discusses the therapeutic strategies developed to date.

RESEARCH ARTICLES

Premature aging in telomerase-deficient zebrafish

Monique Anchelin, Francisca Alcaraz-Pérez, Carlos M. Martínez, Manuel Bernabé-García, Victoriano Mulero, María L. Cayuela

Disease Models & Mechanisms 2013 6: 1101-1112; doi: 10.1242/dmm.011635

N-terminal acetylation and replicative age affect proteasome localization and cell fitness during aging

Sjoerd van Deventer, Victoria Menendez-Benito, Fred van Leeuwen, Jacques Neefjes

J Cell Sci 2015 128: 109-117; doi: 10.1242/jcs.157354

Telomere dynamics in free-living edible dormice (Glis glis): the impact of hibernation and food supply

Franz Hoelzl, Jessica S. Cornils, Steve Smith, Yoshan Moodley, Thomas Ruf

Journal of Experimental Biology 2016 219: 2469-2474; doi: 10.1242/jeb.140871

Highlighted Article: Telomeres in edible dormice shorten over the hibernation season, but these long-lived rodents are able to fully restore telomeres during summer if food supply is sufficient.

Variation in early-life telomere dynamics in a long-lived bird: links to environmental conditions and survival

Hannah Watson, Mark Bolton, Pat Monaghan

Journal of Experimental Biology 2015 218: 668-674; doi: 10.1242/jeb.104265

Summary: The environment strongly influences early-life telomere attrition, suggesting that telomere dynamics may underlie cohort effects often observed in natural populations and may mechanistically link early-life stress and later-life performance.

Aging influences steroid hormone release by mink ovaries and their response to leptin and IGF-I

Alexander V. Sirotkin, Dušan Mertin, Karin Süvegová, Abdel Halim Harrath, Jan Kotwica

Biology Open 2016 5: 174-177; doi: 10.1242/bio.016436

Summary: Both leptin and IGF-I are involved in the control of mink ovarian steroid hormone release. Reproductive aging can be due to (a) reduction in basal progesterone release and (b) alterations in the response of estradiol but not of progesterone to leptin and IGF-I.