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Blood disorders: models, mechanisms and therapies

Organisers: Monica Justice, Nancy Speck, Paresh Vyas and Leonard Zon

Date: 29 September - 1 October 2019

Location: Joseph B. Martin Conference Center, Boston, USA

Advancing basic research findings to the clinic remains a daunting task. Researchers in the field of hematopoiesis have made significant progress in this regard by taking discoveries from model organisms to the clinic. Such advances, including bone marrow transfers, stem cell replacements and immunotherapies, have also had a large impact on the treatment of non-blood disorders.

This meeting on blood disorders and their treatment, organised by the journal Disease Models & Mechanisms, is curated by Editor-in-Chief Monica Justice, Nancy Speck, Paresh Vyas and Leonard Zon. The meeting will bring together diverse front-line researchers, stimulating discussions across basic research and clinical disciplines, and fostering collaborative links among researchers.

Talks will feature basic research advances acquired across multiple model organisms, as they are applied to human blood disorders. A primary aim is to promote knowledge of therapies or drug discovery that has been developed pre-clinically to move to a clinical trial.

Topics:

  • Blood development: mechanisms and pathology
  • Epigenetic regulation of blood development
  • Erythropoiesis and red cell disorders
  • Targeting blood cancers
  • Clonal hematopoiesis
  • Manipulating the stem cell niche

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